Pinealon Reconstitution Calculator
Calculate reconstitution volumes, syringe draw amounts, and doses per vial for Pinealon.
- Concentration
- 50 mcg per unit
- Doses per vial
- 100
100 mcg = 2 units · 0.02 ml
This information is for research only. Not intended for human use.
How to reconstitute Pinealon
- Reconstitute a 10 mg vial of lyophilized Pinealon with 2 mL of bacteriostatic water.
- Add the diluent slowly down the vial wall and swirl gently; do not shake.
- If any particulate or cloudiness remains, filter through a 0.22 µm syringe filter.
- Refrigerate reconstituted Pinealon at 2 to 8°C.
- Discard after 14 days if bacteriostatic water was used, or after 24 to 48 hours for sterile water.
Frequently asked questions
What is Pinealon and what is the evidence for its use?+
Pinealon is the synthetic tripeptide Glu-Asp-Arg (EDR). Mechanistic data show it partially penetrates the DNA major groove at guanine N7/O6, and review-level evidence proposes downstream regulation of MAPK/ERK, caspase-3/p53, and antioxidant enzymes SOD2/GPX1. In Huntington’s disease mice, EDR restored striatal dendritic spine morphology; in elderly donor-derived induced neurons, EDR reduced oxidative DNA damage and increased dendritogenesis. In non-human primates, course administration improved cognition and neuroimmunoendocrine balance. Evidence level: preclinical (animal/in vitro); no controlled human trial identified.
Is Pinealon FDA-approved?+
No. The reviewed literature describes preclinical research only; no FDA-approved indication exists.
What dose is typically used?+
No human dose-finding trial was identified. Primate and rodent studies report course administration but not standardized human doses. Community protocols generally use 50–200 mcg/day subcutaneous or 100–500 mcg/day intranasal for 10–20 days, then an equal off-period (community protocol). No data support exceeding 200 mcg/day subcutaneous or 500 mcg/day intranasal.
Is subcutaneous or oral better?+
No human pharmacokinetic or route-comparison data exist. Pinealon is a small tripeptide with direct DNA-binding activity; community practice favors intranasal or subcutaneous dosing to avoid first-pass degradation (community protocol). Oral bioavailability is not established.
Can I use Pinealon while pregnant or breastfeeding?+
No human reproductive safety data exist. Available studies are in rodents, non-human primates, and cell models. Avoid use during pregnancy and lactation (practitioner consensus).
How long can I take Pinealon?+
Long-term human safety is unknown. Animal/primate studies used intermittent courses. Community protocols typically use 10–20 day cycles with equal-length breaks; continuous daily use lacks evidence (community protocol).
How does Pinealon compare to Epitalon?+
Pinealon is Glu-Asp-Arg, while Epitalon is Ala-Glu-Asp-Gly (AEDG). Both appear in Russian peptide bioregulator research; Epitalon is linked to pineal/melatonin and antioxidant effects, whereas Pinealon studies emphasize DNA binding, NMDA receptor gene expression, and cognitive/neuroprotective effects. No head-to-head comparative data exist.
Does Pinealon need refrigeration?+
No compound-specific stability data were found. Standard peptide handling: store lyophilized product refrigerated or frozen; keep reconstituted Pinealon at 2–8°C and use within 14–30 days; avoid repeated freeze-thaw cycles (community protocol).
Researching Pinealon?
Read the full Pinealon profile for mechanism, protocols, and cited research, or ask ChatPEP directly.