Weight metabolic
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Studies5 min read
Semaglutide studies show kidney and heart changes beyond weight loss
Three new studies looked beyond the scale at semaglutide: a human kidney trial, animal heart failure models, and a UK digital weight-loss program. The results add detail on kidney blood flow and scarring, heart and liver remodeling, and the role of weight tracking.
Studies5 min read
Orforglipron 36 mg lowered weight and blood sugar more than 12 mg
A pooled analysis of six trials found that 36 mg of orforglipron produced larger reductions in weight, waist size, and blood sugar than 12 mg, with similar gastrointestinal side effects. A separate Japanese study reported mostly mild side effects over one year.
Compound pages
The evergreen research summaries these posts build on.
SemaglutideLong-acting GLP-1 receptor agonist for diabetes and weight management.DulaglutideOnce-weekly GLP-1 agonist for type 2 diabetes and heart-risk reduction.LiraglutideA once-daily GLP-1 injection approved for weight loss and diabetes.CagrilintideOnce-weekly investigational amylin analogue for weight management.OrforglipronOnce-daily oral GLP-1 receptor agonist for weight management.